Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars
- 12 May 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 48 (22), 4030-4033
- https://doi.org/10.1002/anie.200806319
Abstract
Sialome sweet sialome: As sialic acids are involved in many host–pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N‐(4‐pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.Keywords
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