Sodium polyanethol sulfonate inactivation of aminoglycosides
Open Access
- 1 August 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 20 (2), 272-274
- https://doi.org/10.1128/aac.20.2.272
Abstract
Sodium polyanethol sulfonate and another polyanion (dextran sulfate) both inhibited aminoglycoside activity in vitro. This effect was not produced by an otherwise similar neutral carbohydrate (dextran) or by neutral detergents (Brij-35, Triton X-100) but was antagonized by an anion-exchange resin (Dowex 1X8-50). We conclude that the inactivation of aminoglycosides by sodium polyanethol sulfonate results from its polyanionic nature and is unrelated to its detergent properties.This publication has 9 references indexed in Scilit:
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