In vivo persistence of sister chromatid exchanges (SCE) induced by gamma rays in mouse bone marrow cells
- 1 January 1984
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 6 (4), 529-537
- https://doi.org/10.1002/em.2860060406
Abstract
The sister chromatid exchange (SCE) frequencies induced in bone marrow cells by in vivo irradiation with gamma rays before or after bromodeoxyuridine (Brdurd) incorporation were compared. The frequency of SCE at different postir‐radiation times was also measured in bone marrow cells in vivo, irradiated before Brdurd incorporation. Increased sensitivity to SCE induction by radiation was found in cells after Brdurd incorporation for one cycle when compared with cells irradiated before Brdurd incorporation. The increased SCE frequency persisted for at least 72 hr after the initial irradiation, implying that the gamma ray‐induced lesion(s) capable of eliciting an SCE are persistent and cannot be easily repaired.Keywords
This publication has 25 references indexed in Scilit:
- Production of sister chromatid exchanges by X-rays under aerobic and anaerobic conditionsHereditas, 2009
- Kinetics of induction of sister-chromatid exchanges by X-rays through two cell cyclesMutation Research, 1982
- Sister-chromatid exchange induction in Chinese hamster ovary cells by 8-methoxypsoralen and brief pulses of laser light assessment of the relative importance of 8-methoxypsoralen—DNA monoadducts and crosslinksMutation Research, 1981
- The relationship between the cell time available for repair and the effectiveness of a damaging treatment in provoking the formation of sister-chromatid exchangesMutation Research, 1980
- Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cellsMutation Research, 1980
- X irradiation and sister chromatid exchange in cultured human lymphocytesEnvironmental Mutagenesis, 1980
- In vivo sister-chromatid exchange: A sensitive measure of DNA damageMutation Research, 1979
- The relevance of caffeine post-treatment to SCE incidence induced in Chinese hamster cellsMutation Research, 1979
- Sister-chromatid exchange induced by X-ray of human lymphocytes and the effect of l-cysteineMutation Research, 1978