EFFECT OF CYCLOHEXIMIDE ON DECIDUOMA MORPHOGENESIS AND IMPLANTATION IN RATS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 27 (4), 238-241
Abstract
I.p. administration of cycloheximide (1 mg/kg body wt) to rats immediately after an artifical deciduoma induction inhibits the development of decidual tissue. Besides inhibiting the differentiation of stromal to decidual cells, wet weight and levels of uterine protein and RNA are low following the antibiotic treatment. Injection of the drug (1 mg/kg body wt) into pregnant rats, either on the eve of day 4 or in the morning of day 5 of pregnancy, does not prevent implantation but interferes with growth of embryos.