Higher Expression of the Heterogeneous Nuclear Ribonucleoprotein K in Melanoma
- 25 May 2010
- journal article
- Published by Springer Nature in Annals of Surgical Oncology
- Vol. 17 (10), 2619-2627
- https://doi.org/10.1245/s10434-010-1121-1
Abstract
The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions strongly indicate that hnRNP K is involved in tumorigenesis. Oncogenes c-Src, c-myc, and eIF4E are regulated by hnRNP K. We have shown an increased cytoplasmic hnRNP K in pancreatic cancer. In the present study, we investigated the altered expression of hnRNP K protein and its correlation with p-ERK in melanoma using human melanoma cell lines and tissue microarray.Keywords
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