A Simple Method of Dithioacetal—and Ketalization

Abstract

Dithioacetals and ketals are useful synthetic intermediates.¹ In general, they are obtained by the acidcatalysed addition of thiol to carbonyl compounds.² The reaction is however a reversible one, and an excess of thiol together with continuous removal of water are often required for optimum yield. Recently, it was reported³ that methylthiotrimethylsilane converted carbonyl compounds to dithioacetals and ketals. The reaction however can not be applied to other thiols.