TRIETHYLCHOLINE COMPARED WITH OTHER SUBSTANCES AFFECTING NEUROMUSCULAR TRANSMISSION
Open Access
- 1 August 1962
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 19 (1), 198-218
- https://doi.org/10.1111/j.1476-5381.1962.tb01440.x
Abstract
Triethylcholine (triethyl-2-hydroxyethyl ammonium) has been compared, in its actions on neuromuscular transmission, with the motor end-plate blocking drugs tubocurarine and decamethonium, with the anticholinesterase neostigmine, and with the closely related drug tetraethylammonium. The experiments were carried out on conscious rabbits and mice, on the tibialis anterior muscle of cats under chloralose anaesthesia and on the isolated phrenic nerve-diaphragm preparation of the rat. Anticholinesterase activity was determined manometrically using the Warburg apparatus. Triethylcholine possessed a slight curare-like action, but this effect was shown to be too weak and transient to contribute to the slowly developing and long-lasting transmission failure which occurs selectively in frequently excited nerve-muscle preparations and in exercised conscious animals. It was confirmed that the site of the blocking action of triethylcholine was pre-junctional. Triethylcholine often produced a slight potentiation of the contractions before blocking them. This effect was not due to a depolarizing or an anticholinesterase action, and it was concluded that the slight initial facilitating action of triethylcholine on neuromuscular transmission was due to an increase in the quantity of acetylcholine released by the nerve impulse. Tetraethylammonium was much more powerful than triethylcholine in this respect. The pre-junctional transmission failure produced by triethylcholine could not be explained simply on the basis that an initial excessive release led to exhaustion of transmitter.Keywords
This publication has 35 references indexed in Scilit:
- The Anticurare Activity of Tetraethylammonium (TEA).Acta Pharmacologica et Toxicologica, 2009
- The neuromuscular blocking action of substances related to cholineInternational Journal of Neuropharmacology, 1962
- Hemicholinium No. 3 and Mammalian Neuromuscular TransmissionNature, 1962
- THE TRIETHYL ANALOGUE OF CHOLINE AND NEUROMUSCULAR TRANSMISSION: A Suggestion for its Trial in Neurogenic Spastic StatesThe Lancet, 1961
- ACTIVITY OF THE TRIETHYL ANALOGUE OF CHOLINE IN SUPPRESSING EXPERIMENTAL TETANUSThe Lancet, 1961
- POSTSYNAPTIC EFFECTS OF HC-3 AT THE NEUROMUSCULAR JUNCTION OF THE FROGCanadian Journal of Biochemistry and Physiology, 1961
- EFFECTS OF RATE OF STIMULATION AND OF FATIGUE ON THE RESPONSE TO NEUROMUSCULAR BLOCKING AGENTSBritish Journal of Pharmacology and Chemotherapy, 1958
- The Effect of Low Calcium and of Tetraethyl‐ammonium (TEA) on the Rat Diaphragm.Acta Physiologica Scandinavica, 1957
- THE SPECIFICITY OF BRAIN CHOLINE ACETYLASEBritish Journal of Pharmacology and Chemotherapy, 1956
- THE SPECIFICITY OF THE TRIMETHYLAMMONIUM GROUP IN ACETYLCHOLINEBritish Journal of Pharmacology and Chemotherapy, 1949