Detection of Normal and Malignant Megakaryocytes by Anti β-Thromboglobulin Serum
- 24 April 2009
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 29 (3), 200-206
- https://doi.org/10.1111/j.1600-0609.1982.tb00583.x
Abstract
An antiserum to .beta.-thromboglobulin was used in immunofluorescence to detect normal and malignant [human] megakaryocytes. In normal peripheral blood and bone marrow smears, only platelets and megakaryocytes were specifically stained by this antiserum. Among 25 cases of acute lymphoid and nonlymphoid leukemia, only 2 exhibited a clear positivity in a percentage of blasts, thus proving their megakaryocytic origin. This method is proposed as a simple and useful tool to detect normal and malignant megakaryoctes on smears.Keywords
This publication has 10 references indexed in Scilit:
- Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reactionBlood, 1981
- Immunofluorescent identification of human megakaryocyte colonies using an antiplatelet glycoprotein antiserumBlood, 1981
- MEGAKARYOBLASTIC LEUKEMIA PRESENTING AS ACUTE MYELOFIBROSIS - A STUDY OF 4 CASES WITH THE PLATELET-PEROXIDASE REACTION1981
- Platelet factor 4 antigen in megakaryocytesThrombosis Research, 1980
- Myeloproliferative Disorders Terminating in Acute Micromegakaryoblastic LeukaemiaBritish Journal of Haematology, 1979
- Platelet alpha-granule proteins: studies on release and subcellular localizationBlood, 1979
- PLATELET ALPHA-GRANULE PROTEINS - STUDIES ON RELEASE AND SUBCELLULAR-LOCALIZATION1979
- Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidaseBlood, 1978
- Megakaryoblastic transformation of chronic granulocytic leukaemia. An electron microscopy and cytochemial study.Journal of Clinical Pathology, 1977