The asphyxia of a chloralized dog by tracheal occlusion produces a strong discharge of adrenalin after 2-5 min., with a maximum in the 5-6th min. Up to 0.045 mgm. per min. from each adrenal can be obtained. The adrenal discharge produces vasoconstriction in a denerved paw and accelerates a denerved heart. If by vascular anastomosis the venous blood of an adrenal gland is passed into the jugular of a 2nd (receiving) dog, there may be observed in the latter the results of the "asphyxial adrenal discharge": an increase of arterial pressure; acceleration of the denerved heart; and constriction of the spleen or of a denerved paw. Discharge of adrenalin can be observed in animals asphyxiated by curare, cobra venom, and injection of KCN. The hypersecretion is due to excitation of the adrenalinosecretory centers by diminution of O, while augmentation of CO2 is much less marked. Innervation of the adrenals hinders the discharge of adrenalin at the time of asphyxia.