GASTRIC SECRETION IN THE ADRENALECTOMIZED RAT

Abstract

TUERKISCHER and Wertheimer (1945) using a modification of the technique for the study of gastric secretion first reported by Roe and Dyer (1939) found a significant decrease in gastric secretion in adrenal-ectomized rats. They particularly emphasized the point that this decrease in gastric secretion could not be accounted for by the surgical trauma imposed upon the animal. A normal volume of secretion was obtained after bilateral adrenal-enucleation. The decrease in gastric secretion following adrenalectomy could be corrected with adrenal cortical extract but not with desoxycorticosterone acetate or normal saline. It seemed important to attempt to confirm these findings. The results herein reported extend and confirm those published elsewhere (Madden and Ramsburg, 1951).