Dose-dependent effects of heroin on memory in two inbred strains of mice
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 67 (3), 235-239
- https://doi.org/10.1007/bf00431262
Abstract
Heroin was administered to DBA/2 and C57BL/6 mice, trained in the five-choice Yerkes-Thompson-Bryant-Bovet-Nitti apparatus for pattern discrimination, in two sets of experiments. In a first set, pretrial administrations of heroin (0.1, 0.25, or 0.5 mg/kg) improved performance in both strains. In a second set, heroin (0.5 mg/kg) immediately following each training session were followed by performance improvements in both strains, while the performance of C57 mice was improved and that of the DBA mice was impaired by 5 mg/kg of opiate. No effect was evident in this set of experiments when heroin was injected 2 h after each session, suggesting that effects of the pretrial treatments were due to influences of the opiate on the consolidation processes of the strains tested.This publication has 12 references indexed in Scilit:
- Effects of pre- and post-trial caffeine administrations on simultaneous visual discrimination in three inbred strains of micePsychopharmacology, 1977
- Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of micePsychopharmacology, 1976
- Acute effects of morphine and chlorpromazine on the acquisition of shuttle box conditioned avoidance responsePsychopharmacology, 1976
- Effects of morphine and heroin on discrimination learning and consolidation in micePsychopharmacology, 1975
- A genetic analysis of morphine-induced running and analgesia in the mousePsychopharmacology, 1975
- Correlation of Behavioural Differences in Three Strains of Mice with Differences in Brain AminesNature, 1974
- Genotype-dependent sensitivity and tolerance to morphine and heroin: Dissociation between opiate-induced running and analgesia in the mousePsychopharmacology, 1974
- Differential effects of morphine on active avoidance as a function of pre-drug performancePharmacological Research Communications, 1973
- [Cholinergic system enzymes in the F 1 hybrids of mice differing in their capacity for conditioning].1973
- Facilitation of simultaneous visual discrimination by nicotine in four ?inbred? strains of micePsychopharmacology, 1969