Combined treatment of advanced malignant melanoma with coumarin and cimetidine
- 31 March 1987
- journal article
- research article
- Published by Springer Nature in Cancer Immunology, Immunotherapy
- Vol. 24 (2), 178-179
- https://doi.org/10.1007/bf00205597
Abstract
Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma. Induction therapy with coumarin 100 mg daily was given for 8 weeks, whereupon cimetidine 1000 mg daily was added. No patients had been previously treated with cytotoxic drugs, and all patients had a good performance status. In 16 patients progressive disease was observed, and only 1 patient experienced no change in condition, lasting 30 weeks. We conclude that treatment with this schedule of coumarin and cimetidine is without effect in advanced malignant melanoma.Keywords
This publication has 2 references indexed in Scilit:
- Endocrine treatment with anti-estrogen, anti-androgen or progestagen of advanced malignant melanoma: Three consecutive phase II trialsEuropean Journal of Cancer and Clinical Oncology, 1985
- Metastatic malignant melanoma: Regression induced by combined treatment with interferon [HuIFN-α(Le)] and cimetidineInternational Journal of Cancer, 1983