Bile Duct Obstruction and Regeneration of the Liver.

Abstract

DNA synthesis and mitosis in liver cells is partially inhibited, 24 hours after operation, in rats subjected to both partial hepatectomy and bile duct obstruction; at 48 hours it is greater, than after partial hepatectomy alone, although not as marked as that seen at 24 hours after partial hepatectomy. Liver cell proliferation occurs 40 to 48 hours after obstruction of the common bile duct, and presumably the result of histologically inapparent injury to liver cells.