Ethanol-induced Depression of Hypoxic Drive and Reversal by Naloxone-A Sex Difference

Abstract

The effects of ethanol ingestion and subsequent intravenously administered naloxone on the ventilatory response to hypercapnic hypoxia in 8 normal males and 8 normal females were examined. The responses of controls were lower in the females (-0.63 .+-. 0.07 L/min/% SaO2) than the males (-1.11 .+-. 0.18 L/min/%SaO2). Alcohol depressed the male response to a mean of -0.50 .+-. 0.08 L/min/%SaO2 (p < 0.01) but increased the mean female response to -0.87 .+-. 0.11 L/min/%SaO2 (p < 0.01). Naloxone reversed the ethanol-induced depression of the hypercapnic hypoxic resonse in males, but had no effect on the female response. In males there was a direct correlation between the magnitude of the initial hypoxic response and the extent of depression by ethanol; the higher the response the greater the depression. Females showed a significant direct correlation between the blood alcohol and the increase in hypercapnic hypoxic slope, whereas males showed a weaker inverse correlation to blood alcohol level. These results demonstrate that ethanol depresses male but not female hypoxic ventilatory responsiveness and suggest that this is mediated by opioid-like mechanisms. Because the alcohol-induced depression was seen in subjects with a high control hypoxic response, the male-female difference might simply reflect initially lower control responses in females. This suggests a qualitative difference in hypoxic ventilatory control mechanisms between sexes.