An enantiomerically pure α-sulphinyl-N,N-dimethylacetamide: a new, efficient reagent for enantioselective aldol-type condensation

Abstract

Asymmetric synthesis (up to 99%) of β-hydroxy-N,N-dimethylacetamides was achieved starting from aldehydes and an optically active sulphoxide containing synthon, the sense of chiral discrimination depending on the intermediate metal enolate.