Analgesic-Associated Nephropathy

Abstract

Since 1953, when Spühler and Zollinger reported from Switzerland the association of chronic interstitial nephritis with the ingestion of certain analgesic drugs,¹ analgesic-associated nephropathy has been established as an important cause of chronic renal disease in many parts of the world. By 1970, reports of chronic renal disease in patients taking large quantities of either over-the-counter remedies or prescription medications containing various analgesics had appeared from many countries in Western Europe as well as from Australia, South Africa and Canada. In contrast to the thousands of cases reported from abroad, by 1970 only 100 cases of analgesic-associated nephropathy had been . . .