Total-Body Irradiation with a High-Dose-Rate Linear Accelerator for Bone-Marrow Transplantation in Aplastic Anemia and Neoplastic Disease

Abstract
Nine children with various hematologic disorders underwent bone-marrow transplantation following total-body irradiation with 750 rad at a rate of 26 rad/min from a 13-MeV linear accelerator in conjunction with cyotoxic drugs. This treatment was tolerated reasonably well, with acceptable side effects. Three patients were alive and well at 18, 11 and 7 mo. post-transplantation.

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