Macromolecular Inhibitor of Fertilization in Rabbit Seminal Plasma
- 1 May 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (5), 951-955
- https://doi.org/10.1073/pnas.68.5.951
Abstract
A large (86S) glycoprotein isolated from rabbit seminal plasma acts on sperm cells to block fertilization. The proportion of fertilized eggs recovered from does 1 day after tubal insemination of sperm 5-6 hr before or 2-3 hr after ovulation was significantly depressed when uterine-capacitated spermatozoa were exposed to this substance at concentrations of 20-72 mug of protein/ml. Rabbit seminal plasma was estimated to have about 2 mg/ml of this factor. Another large glycoprotein ( approximately 138S) is also present in rabbit seminal plasma; the function of this molecule awaits elucidation.Keywords
This publication has 7 references indexed in Scilit:
- Sperm capacitation and fertilization in mammals.1970
- CHARACTERIZATION AND ISOLATION OF A SPERM-COATING ANTIGEN FROM RABBIT SEMINAL PLASMA WITH CAPACITY TO BLOCK FERTILIZATIONReproduction, 1969
- Removal of decapacitation factor from seminal plasma by high-speed centrifugationAmerican Journal of Physiology-Legacy Content, 1961
- FATTY ACID SYNTHESIS IN ADIPOSE TISSUE .1. PURIFICATION AND PROPERTIES OF A LONG CHAIN FATTY ACID-SYNTHESIZING SYSTEM1961
- A Detrimental Effect of Seminal Plasma on the Fertilizing Capacity of SpermNature, 1957
- Fertilizing Capacity of Spermatozoa deposited into the Fallopian TubesNature, 1951
- Observations on the Penetration of the Sperm into the Mammalian EggAustralian Journal of Biological Sciences, 1951