ÜBER DEN EINFLUSS VON CORTISON AUF DIE RIBONUCLEINSÄURE DER RATTENLEBER

Abstract

If rats are treated with relatively high doses of cortisone the total ribonucleic acid (RNA) and protein content in the liver increases. All fractions of the liver are concerned approximately to the same extent. Histologically, the liver cells do not behave uniformly. Under cortisone, the liver cells in the periphery of the lobule show less total RNA (gallocyanin) and a perinuclear area without RNA. The cells in the center of the lobule are histologically not different from the controls. Analysis of the RNA showed no evidence that the ethanol-precipitable RNA disappears from the micro-somes and mitochondria of the liver after cortisone treatment.