Familial Reticuloendotheliosis with Eosinophilia

Abstract

REPORTS of proliferative and infiltrative disorders of the reticuloendothelial system in children have documented a fascinating and frustrating category of disease. Most of these cases of multiorgan involvement and of unknown etiology have in common a proliferation of histiocytes in the tissues and a lack of evidence of inheritance.^{1 , 2} However, several families have been described in which 2 or more children have developed an illness resembling the Letterer–Siwe syndrome.^{3 , 4} Whether this incidence represents genetic transmission, common exposure to some environmental agent or organism or merely chance is unclear. No known family has been affected in more than 1 sibship.This . . .