Homologous repair of DNA damage and tumorigenesis:the BRCA connection
Open Access
- 16 December 2002
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 21 (58), 8981-8993
- https://doi.org/10.1038/sj.onc.1206176
Abstract
Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCA1 and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals against tumorigenesis. This review summarizes recent advances in our understanding of BRCA1 and BRCA2 in DNA repair, as well as insight into these proteins gleaned from structure determination of domains of these proteins and the broader evolutionary conservation than previously appreciated.Keywords
This publication has 108 references indexed in Scilit:
- Insights into DNA recombination from the structure of a RAD51–BRCA2 complexNature, 2002
- Absence of major defects in non-homologous DNA end joining in human breast cancer cell linesOncogene, 2002
- Deficiency in BRCA2 leads to increase in non-conservative homologous recombinationOncogene, 2002
- BARD1 Induces BRCA1 Intranuclear Foci Formation by Increasing RING-dependent BRCA1 Nuclear Import and Inhibiting BRCA1 Nuclear ExportJournal of Biological Chemistry, 2002
- A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joiningOncogene, 2002
- Conserved domains in the chicken homologue of BRCA2Oncogene, 2002
- Nine novel conserved motifs in BRCA1 identified by the chicken orthologueOncogene, 2001
- Nuclear Localization Signals of the BRCA2 ProteinBiochemical and Biophysical Research Communications, 2000
- BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgeneOncogene, 1999
- Identification of a RING protein that can interact in vivo with the BRCA1 gene productNature Genetics, 1996