Decreased tuftsin concentrations in patients who have undergone splenectomy.
- 17 December 1977
- Vol. 2 (6102), 1574-1576
- https://doi.org/10.1136/bmj.2.6102.1574
Abstract
Serum tuftsin concentrations were measured, using a radioimmunoassay developed in Israel, in normal subjects and in patients who had undergone splenectomy. Concentrations in those who had undergone traumatic and elective splenectomy were much lower. The tuftsin concentration in 38 patients with Hodgkin's disease who had undergone splenectomy during staging laparotomy was not significantly different from the mean concentration in other patients who had had elective splenectomy. In four patients who underwent splenectomy for non-malignant haematological disorders measurements made before and after operation showed that tuftsin concentrations fell significantly in the days after operation. The increased susceptibility to overwhelming infections of patients with Hodgkin's disease and others who have undergone splenectomy may be related to the low tuftsin concentrations. As pre-splenectomy tuftsin concentrations in patients with Hodgkin's disease were normal, the practice of performing staging laparotomy and splenectomy in patients with Hodgkin's disease should perhaps be reconsidered.Keywords
This publication has 13 references indexed in Scilit:
- Sepsis and congenital aspleniaThe Journal of Pediatrics, 1977
- Vincristine for Treatment of Chronic Thrombocytopenia in ChildrenNew England Journal of Medicine, 1977
- Tuftsin and some analogsBiochimica et Biophysica Acta (BBA) - General Subjects, 1977
- IMMUNOLOGICAL ABNORMALITIES IN SPLENIC ATROPHYThe Lancet, 1975
- HYPOSPLENISM IN ULCERATIVE COLITISThe Lancet, 1974
- Defective Phagocytosis Due to Tuftsin Deficiency in Splenectomized SubjectsArchives of Pediatrics & Adolescent Medicine, 1973
- A new phagocytosis-stimulating tetrapeptide hormone, tuftsin, and its role in disease.1972
- Characterization of Postsplenectomy Bacteremia among Patients with and without LymphomaNew England Journal of Medicine, 1972
- ‘Tuftsin’: a Natural Phagocytosis Stimulating PeptideNature, 1970
- Reticuloendothelial System Phagocytic Function in Patients with Hodgkin's Disease*JCI Insight, 1967