Preparation and efficacy of an inactivated subunit vaccine (NFUI BHK) against type 2Herpes simplex virus infection
- 1 November 1978
- journal article
- research article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 166 (1-4), 119-132
- https://doi.org/10.1007/bf02121141
Abstract
A vaccine againstHerpes simplex virus infection was prepared by Nonidet NP 40 and formalin treatment of a type 1, infected-cell extract; virus particles were removed by ultracentrifugation over sucrose. These procedures were not detrimental to the antigenic quality of the vaccine preparation. The vaccine afforded significant protection to experimental type 2 genital herpes virus infection in mice, as adjudged by clinical observations, cytopathological change, and virus yields.This publication has 31 references indexed in Scilit:
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