Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Abstract
In rat pancreatic islets, the glucagon-producing A-cells also contain a GIP-like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross-reactivity of anti-GIP with glucagon. It is concluded either that the A-cells synthesize a GIP-like peptide or that it is taken up from the circulation.