Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′,5′-Monophosphate from Sympathetic Nerve Endings
- 8 July 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4299), 174-176
- https://doi.org/10.1126/science.195336
Abstract
Potassium and norepinephrine stimulate the efflux of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP) from intact pineal glands. The postsynaptic beta-adrenergic receptor mediates the efflux of cyclic AMP. In contrast, the efflux of cyclic GMP requires calcium and intact nerve endings. It appears that sympathetic nerve endings may release cyclic GMP into the synaptic space.Keywords
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