Stimulation of globin-chain initiation by hemin in the reticulocyte cell-free system.
- 1 February 1968
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 59 (2), 582-589
- https://doi.org/10.1073/pnas.59.2.582
Abstract
Experi-mental results were reported with an unfractionated cell-free system from rabbit reticulocytes which suggest that the function of hemin in globin synthesis is not solely in the terminal release of completed nascent chains. The results lead to the hypothesis that heme is specificially involved with an initiation process resulting in continued synthesis of new nascent chains from the amino-terminal valine, and that polysomal integrity is dependent on this function. This suggests a model for the translational control of globin synthesis by heme.This publication has 26 references indexed in Scilit:
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