THE ROLE OF THE PITUITARY-ADRENAL SYSTEM IN CYSTINE-S35INCORPORATION INTO PROTEIN1
- 1 November 1952
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 51 (5), 451-456
- https://doi.org/10.1210/endo-51-5-451
Abstract
The role of the pituitary-adrenal system in the incorporation of cystine-S35 into protein was studied in the fed albino rat. Incorporation was reduced following hypophysectomy or adrenalectomy and was restored by admn. of adrenocorticotropin in the former case and various adrenal steroid prepns. in the latter case. With respect to the adrenalectomized rat, aqueous adrenocortical extract, cortisone acetate, and desoxycorticosterone acetate were all capable of restoring incorporation to control levels. Admn. of adrenocorticotropin to the intact rat resulted in increased cystine-S35 incorporation into protein. Data are presented concerning the effects of growth hormone, insulin and orchidectomy on the incorporation of cystine-S35 into protein.Keywords
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