Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease
- 4 December 1975
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 293 (23), 1174-1178
- https://doi.org/10.1056/nejm197512042932305
Abstract
(First of Three Parts)THE concept of pharmacologic inhibition of platelet reactivity as an approach to antithrombotic therapy has gained considerable support with the recognition of the important role of platelets in thrombus formation, and the identification of drugs that suppress platelet function and retard thrombosis in experimental models.1 2 3 4 5 6 7 8 9 10 11 In the selection of drugs for clinical use, it would be valuable to have in vitro laboratory methods to evaluate efficacy and dosage. No such tests are currently available, and it is not known which aspect of platelet function requires suppression to achieve antithrombotic effects.12 In fact, it is likely that . . .Keywords
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