Enzymatic Activity of a Genetically Altered Tryptophan Synthetase in Neurospora crassa
- 12 June 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 129 (3363), 1614-1615
- https://doi.org/10.1126/science.129.3363.1614
Abstract
Partially purified preparations of certain tryptophan-requiring mutants of Neurospora crassa, which contain a protein (CRM) antigenically related to wild-type tryptophan synthetase, possess indole glycerol phosphate-synthesizing activity. This activity can be inhibited by anti-CRM sera. It is suggested that CRM in such mutants represents a damaged tryptophan synthetase lacking the capacity to react with l-serine.Keywords
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