Mutations in RNA Splicing Machinery in Human Cancers
- 29 December 2011
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 365 (26), 2534-2535
- https://doi.org/10.1056/nejme1111584
Abstract
Massively parallel sequencing of cancer genomes is revealing a panoramic view of the genetic drivers of human neoplasms. In this issue of the Journal, Wang et al.1 describe an analysis of the coding sequences of samples from 91 patients with chronic lymphocytic leukemia. The disease is characterized by the accumulation of mature B lymphocytes, and its genetic basis is being rapidly elucidated.2,3 Wang et al. leveraged the large number of samples studied to identify sets of genes that are critical to the development of chronic lymphocytic leukemia. By sequencing both the malignant lymphocytes (CD19+CD5+) and matched nonmalignant control DNA . . .Keywords
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