Applications of hot-melt extrusion for drug delivery
- 1 December 2008
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 5 (12), 1357-1376
- https://doi.org/10.1517/17425240802583421
Abstract
In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last d...Keywords
This publication has 89 references indexed in Scilit:
- Chemical stability and bioadhesive properties of an ester prodrug of Δ9-tetrahydrocannabinol in poly(ethylene oxide) matrices: Effect of formulation additivesInternational Journal of Pharmaceutics, 2008
- Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matricesEuropean Journal of Pharmaceutics and Biopharmaceutics, 2008
- Polymeric Systems for Amorphous Δ9-Tetrahydrocannabinol Produced by a Hot-melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on StabilityJournal of Pharmaceutical Sciences, 2006
- Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processingJournal of Pharmaceutical Sciences, 2006
- Compression of Controlled-Release Pellets Produced by a Hot-Melt Extrusion and Spheronization ProcessPharmaceutical Development and Technology, 2005
- Water vapor sorption of hot‐melt extruded hydroxypropyl cellulose films: Effect on physico‐mechanical properties, release characteristics, and stabilityJournal of Pharmaceutical Sciences, 2004
- Melt-Extruded Molecular DispersionsPublished by Taylor & Francis ,2003
- Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization processJournal of Microencapsulation, 2003
- Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization processJournal of Microencapsulation, 2003
- In Vivo Performance of Wax Matrix Granules Prepared by a Twin-Screw Compounding ExtruderDrug Development and Industrial Pharmacy, 1999