Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep Apnea
- 1 December 1985
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 103 (6_Part_1), 850-855
- https://doi.org/10.7326/0003-4819-103-6-850
Abstract
The therapeutic effects of weight loss were evaluated in 15 hypersomnolent patients with moderately severe obstructive sleep apnea. As patients decreased their body weight from 106.2 .+-. 7.3 kg (mean .+-. SE) to 96.6 .+-. 5.9 kg, apnea frequency fell from 55.0 .+-. 7.5 to 29.2 .+-. 7.1 episodes/h (p < 0.01) in non-rapid-eye-movement sleep with an associated significant decline in the mean oxyhemoglobin saturation during the remaining episodes of sleep apnea from 11.9 .+-. 2.4% to 7.9 .+-. 1.9% (p < 0.02). Sleep patterns also improved, with a reduction in stage I sleep from 40.2 .+-. 7.3% to 23.5 .+-. 4.8% (p < 0.01), and a rise in stage II sleep from 37.3 .+-. 7.0% to 49.4 .+-. 4.6% (p < 0.03). In the 9 patients with the most marked fall in apnea frequency, the tendency toward daytime hypersomnolence was decreased (p < 0.05). No significant changes in sleep patterns occurred in 8 age- and weight-matched control patients who did not lose weight. Moderate weight loss alone can alleviate sleep apnea, improve sleep architecture, and decrease daytime hypersomnolence.Keywords
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