Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
- 1 March 1998
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 75 (1), 111-119
- https://doi.org/10.1016/s0304-3959(97)00213-3
Abstract
Central antinociceptive effects of cannabinoids have been well documented. However, relatively little is known about the peripheral effects of the cannabinoids on inflammation. In the present study, we evaluated the effects of peripherally administered cannabinoids on three indices of inflamKeywords
This publication has 19 references indexed in Scilit:
- The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein couplingFEBS Letters, 1995
- Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2Life Sciences, 1995
- Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.Proceedings of the National Academy of Sciences, 1995
- Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid ReceptorScience, 1992
- Distribution of cannabinoid receptors in rat brain determined with aminoalkylindolesBrain Research, 1992
- Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyJournal of Neuroscience, 1991
- Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesiaPain, 1990
- A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaPain, 1988
- Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compoundsLife Sciences, 1984
- Screening for Teratogenic Hazards: Nature of the ProblemsAnnual Review of Pharmacology and Toxicology, 1981