Dephosphorylation of phosphorylase kinase by a histone H1‐stimulated phosphoprotein phosphatase

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Abstract
A histone H1-stimulated protein phosphatase isolated from rabbit skeletal muscle dephosphorylated [32P]phosphorylase kinase. The rate of dephosphorylation was markedly increased by 5–50 μg histone H1/ml. Only the α and α' subunits were dephosphorylated in the absence or presence of histone H1. This is consistent with previous results suggesting that the H1-stimulated phosphatase is a type-2 protein phosphatase. The present studies suggest that the histone H1-stimulation is the result of direct interaction of the histone with the phosphatase