Evaluation of Iopamidol in Peripheral Arteriography and Coronary Arteriography with Left Ventriculography

Abstract

Iopamidol 300 mg I/ml was compared with diatriozoate meglumine and diatrizoate sodium 292.5 mg I/ml (DTZ) for efficacy and safety in 196 patients undergoing peripheral arteriography. The film quality in both groups was approximately equivalent. Iopamidol caused significantly less discomfort than DTZ. Four contrast media-associated adverse reactions were noted in the iopamidol group; 12 were reported for the DTZ group. In coronary arteriography with left ventriculography iopamidol 370 mg I/ml was compared with DTZ 370 mg I/ml in 71 patients. Adverse reactions occurred in similar frequencies in both groups. Fewer patients given iopamidol experienced decreases in blood pressure following left coronary artery injections. During coronary arteriography, fewer patients in the iopamidol group demonstrated prolongations in QT duration, increases in R-R interval, and changes in T-wave amplitude. Administration of iopamidol was associated with smaller increases in left ventricular end-diastolic pressure. It is concluded that, when used for these indications, iopamidol offers significant advantages over ionic agents.