Plasma Somatomedins, Endogenous Insulin Secretion, and Growth in Transient Neonatal Diabetes Mellitus*
- 1 January 1981
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 52 (1), 144-147
- https://doi.org/10.1210/jcem-52-1-144
Abstract
Infants with transient neonatal diabetes mellitus are small for gestational age and fail to thrive postnatally unless insulin is administered. The concentrations of insulin-related growth factors were measured in an infant girl with this condition to learn if deficiencies in one or more of these factors is responsible for the impaired growth. Cord blood serum radioimmunoassayable insulin and somatomedin C/insulin-like growth factor I (SMC/IGF-I) were low, but insulin-like growth factor II (IGF-II) measured by a specific radioreceptor assay was normal. Insulin therapy begun on the 4th day of life caused a prompt increase in weight and a delayed rise in SMC-IGF-I. No significant changes in IGF-II were observed. After 2.5 mo., insulin treatment was discontinued. At that time, endogenous insulin secretion was documented by increased urinary C-peptide. Normal growth and SMC/IFG-I levels persisted. Growth failure in this condition may be related not only to a lack of insulin but also to SMC/IGF-I deficiency. A deficiency in IGF-II is not involved.Keywords
This publication has 7 references indexed in Scilit:
- Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*Journal of Clinical Endocrinology & Metabolism, 1980
- The Infant of the Diabetic MotherNew England Journal of Medicine, 1979
- Plasma somatomedin and growth hormone values in children with protein-calorie malnutritionThe Journal of Pediatrics, 1978
- Estimation of Somatomedin-C Levels in Normals and Patients with Pituitary Disease by RadioimmunoassayJCI Insight, 1977
- Somatomedin in Cord Blood: Relationship to Gestational Age and Birth SizeJournal of Clinical Endocrinology & Metabolism, 1976
- Somatomedin-C Receptor Ontogeny and Levels in Porcine Fetal and Human Cord SerumJournal of Clinical Endocrinology & Metabolism, 1976
- The Effects of Insulin and Growth Hormone on the Release of Somatomedin by the Isolated Rat LiverEndocrinology, 1976