Histamine Release in vitro: Inhibition by Catecholamines and Methylxanthines
- 30 August 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3844), 902-903
- https://doi.org/10.1126/science.161.3844.902
Abstract
Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3 ', 5'-adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.Keywords
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