GENE EXPRESSION OF A REGION OF CHROMOSOME 17 DURING MURINE SPERMATOGENESIS
- 1 October 1977
- journal article
- research article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 4 (5), 353-362
- https://doi.org/10.1111/j.1744-313x.1977.tb00918.x
Abstract
The presence of H-2[major histocompatibility locus]-linked gene products on spermatozoa and their time of appearance during spermatogenesis was determined. Thymus leukemia antigen specificities 1, 2 and 3 were not detected on spermatozoa by absorption of the antisera. Immunofluorescent studies with anti-Slp [B 10-Q female anti-B.10WR male serum] sera did not reveal any specific reactivity with target spermatozoa. H-2D antigens were present on somatic as well as germ line components in testes so the time of their 1st appearance during spermatogenesis was not precisely specified. Cell separation experiments indicate that H-2D antigens are present on pachytene spermatocytes and increased in quantity on spermatids. The sperm-specific isoenzyme of phosphoglycerate kinase, Pgk-2, appears at a later stage of spermatogenesis than do the H-2 region antigens.This publication has 29 references indexed in Scilit:
- ABSORPTION ANALYSIS OF H‐2D AND K ANTIGENS ON SPERMATOZOAInternational Journal of Immunogenetics, 1977
- Developmental expression of an early embryonic antigen common to mouse spermatozoa and cleavage embryos, and to human spermatozoa: Its expression during spermatogenesisDevelopmental Biology, 1976
- The T-locus of the mouseCell, 1975
- A model for genetic analysis of programmed gene expression as reflected in the development of membrane antigensDevelopmental Biology, 1975
- H–2 linked Ss protein is C4 component of complementNature, 1975
- A complex genetic locus that controls the first three steps of pyrimidine biosynthesis in DrosophilaNature, 1975
- Genetic control of glucuronidase induction in miceJournal of Molecular Biology, 1973
- A Unique RNA Species from Maturing Mouse SpermatozoaNature, 1973
- Serological Demonstration of H–Y (Male) Antigen on Mouse SpermNature, 1971
- Two Linked Genes showing a similar Timing of Expression in MiceNature, 1961