Synthesis of Oxygen-17 Labeled Alcohols Via Organoborane Reactions
- 1 July 1983
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 13 (9), 737-740
- https://doi.org/10.1080/00397918308063702
Abstract
Oxygen-17 enriched alcohols play an increasingly important role in chemical, biological, and medical research1. Traditionally these reagents are prepared via hydrolysis of a suitable acetal or ketal with oxygen-17 labeled water followed by reduction of the oxygen labeled carbonyl compounds2. This sequence produces good yields of volatile, unsubstituted alcohols but is of limited use in the preparation of materials containing reducible or hydrolyzable functional groups.Keywords
This publication has 5 references indexed in Scilit:
- Rapid incorporation of radiobromine via the reaction of labeled sodium bromide with organoboranesJournal of Radioanalytical and Nuclear Chemistry, 1982
- Mild and convenient oxidation procedure for the conversion of organoboranes to the corresponding alcoholsThe Journal of Organic Chemistry, 1975
- Simple high yield synthesis of methanol-18O and ethanol-18OThe Journal of Organic Chemistry, 1972
- Stoichiometrically controlled reaction of organoboranes with oxygen under very mild conditions to achieve essentially quantitative conversion into alcoholsJournal of the American Chemical Society, 1971
- Electron spin resonance studies of homolytic substitution reactions. Organoboron, -aluminum, and -gallium compoundsJournal of the American Chemical Society, 1969