Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
Top Cited Papers
Open Access
- 11 March 2008
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (10), 3879-3884
- https://doi.org/10.1073/pnas.0800050105
Abstract
Residual viremia can be detected in most HIV-1-infected patients on antiretroviral therapy despite suppression of plasma RNA to R2 = 0.27, P = 0.001 and R2 = 0.19, P < 0.005, respectively), supporting a biological link between the extent of overall baseline viral infection and the infection of long-lived reservoirs. These data suggest that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second in which viral production remains stable for at least 7 years.Keywords
This publication has 33 references indexed in Scilit:
- ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy ViremiaPLoS Pathogens, 2007
- Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4 + T CellsJournal of Virology, 2006
- A long-term latent reservoir for HIV-1: discovery and clinical implicationsJournal of Antimicrobial Chemotherapy, 2004
- Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapyMathematical Biosciences, 2004
- Genotypic Analysis of HIV‐1 Drug Resistance at the Limit of Detection: Virus Production without Evolution in Treated Adults with Undetectable HIV LoadsThe Journal of Infectious Diseases, 2004
- Long-term safety and durable antiretroviral activity of lopinavir/ritonavir in treatment-naive patientsAIDS, 2004
- In a Subset of Subjects on Highly Active Antiretroviral Therapy, Human Immunodeficiency Virus Type 1 RNA in Plasma Decays from 50 to <5 Copies per Milliliter, with a Half-Life of 6 MonthsJournal of Virology, 2003
- Decay characteristics of HIV-1-infected compartments during combination therapyNature, 1997
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience, 1996
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995