ABSENCE OF SPECIFIC MIXED LEUKOCYTE CULTURE REACTIVITY DURING GRAFT-VERSUS-HOST DISEASE AND FOLLOWING BONE MARROW TRANSPLANT REJECTION

Abstract

SUMMARY Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In test of pre- and post-transplant lymphocytes we found no evidence that rejection or graft-versus-host disease was caused by antigens that stimulate in the mixed lymphocyte culture assay.