IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION (VH) MARKER ASSOCIATED WITH CROSS-REACTIVE IDIOTYPES IN MAN
- 1 January 1977
- journal article
- research article
- Vol. 30 (2), 233-241
Abstract
The VH specificities of 2 rabbit antisera raised against the H chains of 2 human Ig[immunoglobulin]M cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They recognized a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii[blood group antigens] antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal .gamma.-globulin and strongly expressed on 8% of unselected myeloma and macroglobulinemia proteins. There is evidence to sugest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.This publication has 27 references indexed in Scilit:
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