RNA interference
Top Cited Papers
- 11 July 2002
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 418 (6894), 244-251
- https://doi.org/10.1038/418244a
Abstract
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.Keywords
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