Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis
Open Access
- 27 October 2005
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 52 (11), 3596-3602
- https://doi.org/10.1002/art.21393
Abstract
Objective Clinical, pharmacologic, and epidemiologic evidence supports the hypothesis that common genetic pathways may underlie inflammatory diseases. In a previous study, a Crohn's disease gene, CARD15, was demonstrated to be associated with psoriatic arthritis (PsA). Recently, a functional haplotype of 2 single‐nucleotide polymorphisms (SNPs) mapping to the organic cation transporter (OCTN) genes, SLC22A4 and SLC22A5, was identified as a second Crohn's disease susceptibility locus. The SLC22A4 gene has also been associated with rheumatoid arthritis. This study was undertaken to further elucidate associations of PsA with Crohn's disease susceptibility genes. Methods Association with CARD15 and OCTN was investigated in UK Caucasian patients with PsA (n = 472) and population controls (n = 594), using 5′ allelic discrimination assays (TaqMan). Two SNPs in OCTN, forming a haplotype previously associated with Crohn's disease, were also tested in patients with psoriasis (n = 218) and patients with early undifferentiated inflammatory arthritis (n = 386). Allele and estimated haplotype frequencies were compared between patients and controls. Results No association of PsA with CARD15 was detected. In contrast, a functional SNP mapping to the promoter region of SLC22A5 (rs2631367) was associated with PsA (for CC versus GG, odds ratio 1.65, 95% confidence interval 1.13–2.41, uncorrected P = 0.005). In addition, the haplotype associated with Crohn's disease was also associated with PsA (P = 0.001). No association was detected in the cohort with psoriasis alone or in the cohort with undifferentiated inflammatory arthritis. Conclusion The OCTN haplotype previously associated with Crohn's disease is also associated with PsA, suggesting that these 2 diseases may share some common genetic control in pathways of inflammation.Keywords
This publication has 32 references indexed in Scilit:
- Pathogenesis of psoriatic arthritisClinical and Experimental Dermatology, 2001
- Mortality studies in psoriatic arthritis: Results from a single outpatient center. II. Prognostic indicators for deathArthritis & Rheumatism, 1998
- Mortality studies in psoriatic arthritis. Results from a single outpatient clinic. I. Causes and risk of deathArthritis & Rheumatism, 1997
- Natural history of psoriatic arthritisBailliere's Clinical Rheumatology, 1994
- PSORIATIC ARTHRITIS (PA): A CLINICAL, IMMUNOLOGICAL AND RADIOLOGICAL STUDY OF 180 PATIENTSRheumatology, 1991
- Outcome in patients hospitalised for psoriatic arthritisClinical Rheumatology, 1989
- PSORIATIC ARTHRITIS IN PSORIATIC PATIENTSRheumatology, 1984
- Arthritis in psoriasis.Annals Of The Rheumatic Diseases, 1981
- Familial occurrence of psoriatic arthritis.Annals Of The Rheumatic Diseases, 1973
- Psoriatic arthritisSeminars in Arthritis and Rheumatism, 1973