Ewing's Sarcoma and the ”Peanut” Tumors

Abstract

The application of molecular biology to the treatment of patients with cancer took root in pediatric oncology with the landmark demonstration of the association of amplification of the N-myc oncogene with a poor prognosis in children with neuroblastoma¹. Today, amplification of N-myc and the amount of DNA in tumor cells are factors that can determine the intensity of therapy for neuroblastoma. Neuroblastoma belongs to a family of primitive small-round-cell tumors, which often cause diagnostic difficulties because of their homogeneous appearance on light microscopy and their frequent lack of organ specificity. Any of these tumors can be hidden in the . . .