Immunoreactive ACTH/?-endorphin neurons in the tubero-infundibular hypothalamus of rats
- 1 May 1982
- journal article
- research article
- Published by Springer Nature in Cell and tissue research
- Vol. 224 (2), 303-314
- https://doi.org/10.1007/bf00216875
Abstract
In the preinfundibular portion of male rat hypothalamus, the arcuate-median eminence region was examined after staining with anti-porcine ACTH 1-39 serum. In several cases, anti-β-endorphin serum was also employed. Both sera stain the same cell bodies. The cell bodies of the immunoreactive neurons are scattered in the subependymal layer, arcuate nucleus and lateral tuberal region. Fibers originating from these cell bodies are distributed extensively throughout these regions. They make synaptic contacts on immunonegative fibers in the arcuate nuclei, or terminate directly in the perivascular space in the internal layer of the median eminence. The fibers, however, are very scarce in the external layer of the median eminence, and do not directly terminate on the neurovascular contact surface. These findings suggest that the ACTH/β-endorphin neuronal system may serve neuronally and humorally as an intrahypothalamic constituent of the hypothalamic pituitary regulation system.This publication has 30 references indexed in Scilit:
- Immunohistochemical Demonstration of LHRH Neurons and Their Pathways in the Rat HypothalamusNeuroendocrinology, 1981
- Location and characterization of opiate receptors regulating pituitary secretionLife Sciences, 1980
- The Hypophysial Portal Circulation TodayNeuroendocrinology, 1980
- Interaction between opiates and hypothalamic dopamine on prolactin releaseLife Sciences, 1979
- Pituitary-Brain Vascular Relations: A New ParadigmScience, 1979
- Brain ACTH and endorphin reduced in rats with monosodium glutamate-induced arcuate nuclear lesionsNature, 1979
- Immunoreactive β‐endorphin and acth in the same neurons of the hypothalamic arcuate nucleus in the ratJournal of Anatomy, 1979
- Evidence for two separate opiate peptide neuronal systemsNature, 1978
- Evidence for pituitary-brain transport of a behaviorally potent acth analogLife Sciences, 1978
- Stimulation of prolactin release in the rat by intraventricular injection of β-end orphin and methionine-enkephalinBiochemical and Biophysical Research Communications, 1977