Mucosal lesions in the human small intestine in shock.
Open Access
- 1 December 1975
- Vol. 16 (12), 979-984
- https://doi.org/10.1136/gut.16.12.979
Abstract
Characteristic mucosal lesions in resected small intestinal segments from seven patients are reported. Preoperatively, four patients were in shock and general hypotension while the three remaining cases showed signs of local intestinal hypotension. The microscopic appearance of the mucosal lesions was in all patients identical with that previously observed in the feline and canine small intestine after haemorrhage or local intestinal hypotension. It is proposed that an extravascular short-circuiting of oxygen in the mucosal countercurrent exchanger and an intravascular aggregation of blood cells might produce tissue hypoxia which makes the mucosa vulnerable to enzymatic degradation.Keywords
This publication has 15 references indexed in Scilit:
- Countercurrent Multiplication of Sodium in Intestinal Villi during Absorption of Sodium ChlorideActa Physiologica Scandinavica, 1973
- Mucosal Lesions in the Small Intestine of the Cat during Low FlowActa Physiologica Scandinavica, 1973
- Mucosal Hemodynamics in the Small Intestine of the Cat during Reduced Perfusion PressureActa Physiologica Scandinavica, 1973
- Mesenteric Circulatory Responses to Hemorrhagic Shock in the BaboonAnnals of Surgery, 1972
- Mesenteric vascular responses to endotoxin in the monkey and dogAmerican Journal of Physiology-Legacy Content, 1970
- Haemorrhagic mucosal necrosis of the gastrointestinal tract without vascular occlusion.1969
- Extravascular Shunting of Oxygen in the Small Intestine of the CatActa Physiologica Scandinavica, 1968
- The Visceral Circulation in ShockGastroenterology, 1967
- Biosynthesis of Intestinal Mucin in ShockAnnals of Surgery, 1966
- THE BOWEL IN SHOCK THE ROLE OF MESENTERIC ARTERIAL DISEASE AS A CAUSE OF DEATH IN THE ELDERLYThe Lancet, 1962