Liver microsome-mediated mutagenicity of dihydrodiols derived from dibenz(a, c)anthracene in S.typhimurium TA100

Abstract

The mutagenic activities of the trans-1,2- and 3,4-diols of dibenz(a,c)anthracene, both of which could yield ‘bay-region’ diol-epoxides on further metabolism, were lower than those of the parent hydrocarbon and of the related 10,11-diol.