Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus–Response Compatibility Task

Abstract

The current study examined the development of cognitive and neural systems involved in overriding a learned action in favor of a new one using a stimulus–response compatibility task and functional magnetic resonance imaging. Eight right-handed adults (mean age, 22–30 years), and eight children (7–11 years) were scanned while they performed a task. Both children and adults were less accurate for incompatible stimulus–response mappings than compatible ones; the children9s performance was significantly worse. The comparison of the incompatible and compatible conditions showed large volumes of activity in the ventral prefrontal cortex, ventral caudate nucleus, thalamus, and hippocampus. Striatal activity correlated with the percentage of errors in overriding the old stimulus–response association. The hippocampal activity correlated with the reaction time to make a response to a new stimulus–response mapping that required the reversal of a prior association between a stimulus and a response location. Developmental differences were observed in the volume of striatal/pallidal and hippocampal/parahippocampal activity in that these regions were larger and extended more ventrally in children relative to adults. These results suggest that with maturation and learning, projections to and from these regions may become more refined and focal. Moreover, these findings are consistent with the role of ventral frontostriatal circuitry in overriding habitual and well learned actions and hippocampal systems in learning and reversing associations between a given stimulus and spatial location.