Studies on the Metabolism ofd-Limonene (p-Mentha-1,8-diene): II. The Metabolic Fate ofd-Limonene in Rabbits
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 4 (2), 85-95
- https://doi.org/10.3109/00498257409049348
Abstract
1. The metabolic fate of d-limonene (p-mentha-1,8-diene) was investigated in the rabbit. 2. Following oral administration of [14C]d-limonene to three male rabbits, about 72% and 7% of the dose was excreted in urine and faeces during 72 h, respectively. 3. Metabolites isolated from the urine after administration of d-limonene were p-mentha-1,8-dien-10-ol, p-menth-1-ene-8,9-diol, perillic acid, perillic acid 8,9-diol, p-mentha-1,8-dien-10-yl-β-D-glucopyranosiduronic acid and 8-hydroxy-p-menth-1-en-9-yl-β-D-glucopyranosiduronic acid.Keywords
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